In a study of systemic hemodynamic function measured invasively in 12 patients with a mean LV ejection fraction of 37% and ventricular tachycardia 9 sustained and 3 non-sustained a median dose of 160 mg twice daily of Betapace produced a 28% reduction in heart rate and a 24% decrease in cardiac index at 2 hours post-dosing at steady-state. Concurrently, systemic vascular resistance and stroke volume showed nonsignificant increases of 25% and 8%, respectively. One patient was discontinued because of worsening congestive heart failure. This medicine is a light blue, oblong, scored tablet imprinted with "BETAPACE" and "120 mg".
National Collegiate Athletic Association. NCAA Banned-Drug Classes 2005-2006. Pellicore, L. S. Developmental toxicity of Citrus aurantium in rats. Birth Defects Res B Dev. The intersubject variation for oral clearance was 22%. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects.
Some MEDICINES MAY INTERACT with Betapace. Sotalol hydrochloride prolongs the plateau phase of the cardiac action potential in the isolated myocyte, as well as in isolated tissue preparations of ventricular or atrial muscle Class III activity. In intact animals it slows heart rate, decreases AV nodal conduction and increases the refractory periods of atrial and ventricular muscle and conduction tissue. These two medicines are taken together to help lower your blood pressure. In some people, they may increase blood pressure. If you stop taking clonidine and continue taking your beta-blocker, or if you stop taking them both at the same time, your blood pressure may also increase.
Bitter orange is a plant. The peel, flower, leaf, fruit, and fruit juice are used to make medicine. Bitter orange oil is made from the peel. AFL, as well as to reduce the risk of such recurrence at both 6 and 12 months. The 120 mg dose was more effective than 80 mg, but 160 mg did not appear to have an added benefit. Note that these doses were given twice or once daily, depending on renal function. Magnesium sulfate is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using magnesium sulfate at home, a health care provider will teach you how to use it. Be sure you understand how to use magnesium sulfate. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. No significant alteration in QRS interval is observed. Take Betapace by mouth with or without food. You should not use this medication if you are allergic to sotalol, or if you have asthma, certain serious heart conditions, a history of Long QT syndrome, severe kidney disease, or low levels of potassium in your blood. A-Fib but like crestor Which is another very scarey drug it is pushed by the pharmc companies. Some times I think these doctors get big kick backs from the med companys to push these meds. Use of sotalol in any age group with decreased renal function should be at lower doses or increased intervals between doses. Sotalol AF may also be used for purposes not listed in this medication guide. Continually monitor patients until steady state blood levels are achieved. Most patients will have satisfactory response with 120 mg twice daily. Magnesium sulfate is to be used only by the patient for whom it is prescribed. Do not share it with other people. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Anxiety before surgery. Research suggests that taking bitter orange two hours before surgery reduces anxiety. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Sotalol is mainly eliminated via the kidneys.
Calapai G, Firenzuoli F, Saitta A, et al. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: A preliminary report. Do not skip doses or stop using sotalol AF without your doctor's advice. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Bagchi, D. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Wise, J. A. The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders. J Strength Cond. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Hohnloser SH, Vandeloo A, Baedeker F "Efficacy and proarrhythmic hazards of pharmacologic cardioversion of atrial fibrillation: prospective comparison of sotalol versus quinidine. Since the half-life of sotalol decreases with decreasing age below about 2 years time to steady-state will also increase. Thus, in neonates the time to steady-state may be as long as a week or longer. Schering-Plough Ltd. February 2, 2006.
Kendrick IP, Harris RC, Kim HJ, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Moderate. These medicines may cause some risk when taken together. The body breaks down dextromethorphan Robitussin DM, others to get rid of it. Bitter orange might decrease how quickly the body breaks down dextromethorphan Robitussin DM, others. Taking bitter orange along with dextromethorphan Robitussin DM, others might increase the effects and side effects of dextromethorphan Robitussin DM, others. Penzak SR, Jann MW, Cold JA, et al. Seville sour orange juice: synephrine content and cardiovascular effects in normotensive adults. For children aged about 2 years or younger, the above pediatric dosage should be reduced by a factor that depends heavily upon age, as shown in the following graph, age plotted on a logarithmic scale in months. Betapace is to be used only by the patient for whom it is prescribed. Do not share it with other people. Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract Citrus aurantium. Betapace sotalol hydrochloride was given as a non-titrated initial dose of 320 mg once daily. Sotalol AF can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. AFL and Relative Risk vs. Your doctor or pharmacist can provide more information about sotalol. Keep all regular medical and laboratory appointments. Continually monitor patients until steady state blood levels are achieved.
VF who were also inducible by PES, the effectiveness acutely and chronically of Betapace was compared with that of 6 other drugs procainamide, quinidine, mexiletine, propafenone, imipramine and pirmenol. Overall response, limited to first randomized drug, was 39% for Betapace and 30% for the pooled other drugs. Acute response rate for first drug randomized using suppression of PES induction was 36% for Betapace vs. a mean of 13% for the other drugs. Using the Holter monitoring endpoint complete suppression of sustained VT, 90% suppression of NSVT, 80% suppression of VPC pairs, and at least 70% suppression of VPCs Betapace yielded 41% response vs. 45% for the other drugs combined. Higgins, C. L. Energy beverages: content and safety. Mayo Clin Proc. Some medications changed by the liver include lovastatin Mevacor ketoconazole Nizoral itraconazole Sporanox fexofenadine Allegra triazolam Halcion and many others. Gray SG, Clair AA. Influence of aromatherapy on medication administration to residential-care residents with dementia and behavioral challenges. Hoffman J, Ratamess NA, Ross R, et al. Beta-alanine and the hormonal response to exercise. QID in reducing VPCs. HCl. The fine solid particles are the water-insoluble inactive ingredients of the tablets. Anastassiades CJ. Nifedipine and beta-blocker drugs. Cherniack, E. P. Potential applications for alternative medicine to treat obesity in an aging population. Altern. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Invega paliperidone US prescribing information. QTc exceeds 550 msec. Gossinger HD, Siostrzonek P, Schmoliner R, Grimm G, Jager U, Mosslacher H "Sotalol-induced torsades de pointes in a patient with pre-existent normal response to programmed ventricular stimulation. Ramadan W, Mourad B, Ibrahim S, Sonbol F. Oil of bitter orange: new topical antifungal agent. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks. D'Andrea G, Terrazzino S, Leon A, et al. Elevated levels of circulating trace amines in primary headaches.
This medicine is a light blue, oval, scored tablet imprinted with "93 62". Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000. Sotalol AF is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Song DK, Suh HW, Jung JS, et al. Antidepressant-like effects of p-synephrine in mouse models of immobility tests. Mielke, M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino. Another form of this medicine, called sotalol Betapace, Sorine is used to treat heart rhythm disorders of the ventricles the lower chambers of the heart that allow blood to flow out of the heart. Sotalol is used in people with ventricular tachycardia or ventricular fibrillation. This information is generalized and not intended as specific medical advice. Vaughan Williams Class III antiarrhythmic properties. Ultane sevoflurane US prescribing information. AbbVie, Inc. From pediatric pharmacokinetic data the following is recommended. If you use antacids containing aluminum or magnesium, do not take them at the same time as sotalol. These antacids can bind to sotalol and decrease its absorption and effectiveness. Separate doses of these antacids and sotalol by at least 2 hours to reduce this interaction.
Beta-adrenergic receptor blocking agents aka beta-blockers in general should not be used in patients with overt congestive heart failure CHF. Sympathetic stimulation may be important in maintaining the hemodynamic function in these patients, thus beta-blockade can worsen the heart failure. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Continue to use Betapace even if you feel well. Do not miss any doses. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. For children aged about 2 years and older, with normal renal function, doses normalized for body surface area are appropriate for both initial and incremental dosing. Fabricant, D. Physiological effects following administration of Citrus aurantium for 28 days in rats. Toxicol.
This medicine is a light orange, round, scored tablet imprinted with "M S24". Steady-state was reached after 1 to 2 days. If there are any changes in the brand or strength of sotalol you use, your dosage needs may change. Inferrera, G. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: a preliminary report. If you have these conditions, read the provided information carefully. Do not switch brands of sotalol without checking with your doctor. This may not be a complete list of all interactions that may occur. Ask your health care provider if Betapace may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Do not start, stop, or change the dosage of any medicine before checking with them first. Toxicol. 2-9-2013; View abstract. Anzemet dolasetron mesylate US prescribing information. Use with care in women. They may have a higher risk of serious irregular heartbeat. Do not skip doses or stop using sotalol without your doctor's advice. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose. Because coronary artery disease may be common, but unrecognized, in patients treated with sotalol, abrupt discontinuation may unmask latent coronary insufficiency. Sotalol is excreted in the milk of laboratory animals and has been reported to be present in human milk. This drug may rarely make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. You will need to have an electrocardiogram ECG before starting Betapace and during treatment. Talk with your doctor. Buckle J. Use of aromatherapy as a complementary treatment for chronic pain. Advise patients who miss a dose to take the next dose at the usual time. Do not double the dose or shorten the dosing interval. Pilon, K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. CMAJ. This medication passes into breast milk and may have undesirable effects on a nursing infant. Discuss the risks and benefits with your doctor before breast-feeding.
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If a suspension has been prepared, shake well before use. Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose. Edurant rilpivirine US prescribing information. Lexapro escitalopram oxalate US prescribing information.
It is unknown whether this product passes into milk. Consult your doctor before -feeding. Allison, D. B. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Betapace AF is not used for the same conditions that Betapace and Sorine are used for.
Noxafil posaconazole UK summary of product characteristics. Torsade de Pointes, however, caution should be exercised regardless of the QTc interval. Do not skip doses or stop taking sotalol without first talking to your doctor. Stopping suddenly may make your condition worse. You may need to use less and less before you stop the medication completely.
Fabricant, D. Cardiovascular Toxicity of Citrus aurantium in Exercised Rats. Cardiovasc. What Are Warnings and Precautions for Sotalol? Tell your doctor or dentist that you take magnesium sulfate before you receive any medical or dental care, emergency care, or surgery. Betapace vs. 2% on placebo.